During the Wolf-359 incident, 39 starships were destroyed, and 11,000 people were killed or assimilated. Why didn’t one of the smaller ships warp into that one Borg cube? Doesn’t warping into it destroy anything? Even if it just warps through without touching, one could program the navicom to self destruct while the ship is in the middle of Borg cube. Answer Trivial, really: The Federation is simply not in the business of Kamikaze suicide runs. And since we haven't seen an entire space-ship piloted per remote in a very reliable manner (not even shuttles), that's exactly what it would have to be. If they dispatch a fleet of 39 ships to apprehend the Borg, they might not be surprised of casualties, but having a ship's crew sacrifice themselves is so horribly incompatible with the spirit of Star Trek (i.e. out-of-universe) and the Federation (in-universe) that Roddenberry'd be spinning like a drill in his grave for the mere suggestion. Having said that, a similar tact...