doctor who - How do Time lords/Gallifreyans breed, and can they do so with humans?

How do Gallifreyans breed? Are they asexual - like Donna asked, 'Do you lop a limb off and sprout another one?'

And can humans and Gallifreyans inter-breed? Eight claimed he was half human on his mothers side, but that doesn't come up in any other incarnation.

Answer

First, I'm going to assume you mean Gallifreyans, because "Time Lord" is not a race.

Second, keep in mind that Doctor Who has no canon; no one in a position of creative or legal authority has ever laid down what is and isn't canon, and the two producers for New Who have both said they don't think canon is possible. That being true, generally off-screen events (audio stories, books, comics, etc) have less ontological inertia than things which actually happen during an episode of the show.

Gallifreyans can probably have children with humans.

...Although it's never happened on screen.

The Doctor's granddaughter Susan married a human in the 22nd century, and one account says that they were unable to have children while another says they did. Neither happened on screen.

The Fourth Doctor's companion Leela married a Gallifreyan Time Lord, and in non-screen materials they had the first natural-born child on Gallifrey in millennia.

Gallifreyan reproduction is not addressed much on screen

And it's pretty inconsistent.

The best I can do is point you at this answer again. The TL;DR is that in non-screen materials Gallifreyan reproduction is largely aided by cloning-like technology, but that this seems to be contradicted by some on-screen evidence that they reproduce more like we do.

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