marvel - How to kill Wolverine?

Wolverine is a tough man, his regeneration power makes him almost indestructible.

In the second X-men movie, Wolverine himself killed Deathstrike, a mutant that had the same regeneration power as him, by injecting her with adamantium. But I also learned recently that Magneto was able to rip all the adamantium out of Wolverine's body ([X-Men volume 2 #25, 1994), so I suppose her death is not final.

Apart from an extreme solution like Nuking him, throwing him into the sun or a black hole, is there a conventional way of killing him?

Answer

The Muramasa Blade

The Muramasa Blade (the second, made specifically for Wolverine - not the Black Blade) has been shown to effectively negate healing factors entirely. It has been used to

scar Wolverine's chest, decapitate Sabertooth, negate Skaar's healing factor (while used by Daken), etc.

It was described by Wolverine as "the only thing in the world that could put him down."

At this point in time, Wolverine removed Daken's Muramasa-coated claws and buried them with the the remains of the broken Muramasa Blade in an unknown location. It has the ability to cut at a molecular level, so it should have no problem slicing through his adamantium. Pair that with the decapitation @phantom42 mentioned, and you'd likely have a dead Logan.

Carbonadium

It's possible Carbonadium, an unstable attempt at Adamantium made by the Russians (more malleable, but cheaper and radioactive) could slow down Wolverine's healing factor enough to kill him. Wolverine had Bucky shoot Daken with a Carbonadium bullet, and one shot was enough to keep Daken from healing temporarily.

Omega Red has Carbonadium tentacles, and Moon Knight's suit supposedly has Carbonadium incorporated in it, but I don't believe either has the volume needed to make a difference against Wolverine's healing factor.

Other Healing Factor Blockers

Considering Wolverine's healing factor is probably a mutant power (with Loeb's Lupine stuff who knows what's actually going on), anything that could suppress or remove that could interfere with his ability to heal (when paired with a way to kill somebody normally). For example, the Savage Land suppresses abilities to some extent. Additionally, other healing factors (Deadpool, recently) have been suppressed by a variety of methods - depending on the method and the writer, they may or may not be strong enough to work on Wolverine.